Isoclox
Flucloxacillin
PRESENTATION
- Isoclox 250 Capsule: Each capsule contains Flucloxacillin Sodium BP equivalent to Flucloxacillin 250mg.
- Isoclox 500 Capsule: Each capsule contains Flucloxacillin Sodium BP equivalent to Flucloxacillin 500mg.
- Isoclox Dry Powder for Suspension: After reconstitution, each 5ml contains Flucloxacillin Sodium BP equivalent to 125mg Flucloxacillin 125mg.
Description: Flucloxacillin is isoxazolyl penicillin which combined the properties of resistance to hydrolysis by penicillinase, gastric acid stability and activity against gram-positive bacteria. Flucloxacillin is a bactericidal antibiotic that is particularly useful against penicillinase-producing staphylococci. Flucloxacillin kills bacterial cell wall, thus interfering with peptidoglycan synthesis. Peptidoglycan is a heteropolymeric structure that provides the cell wall with its mechanical stability. The final stage of peptidoglycan synthesis involves the completion of the cross-linking with the terminal glycine residue of the pentaglycin bridge linking to the fourth residue of the pentapeptide (D-alanine). The transpeptidase enzyme that performs this step is inhibited by Flucloxacillin. As a result the bacterial cell wall is weakened, the cell swells and then ruptures.
Therapeutic Class: Antibiotic
